Evaluating Personalized Language Therapy with Brain Stimulation for Mild Primary Progressive Aphasia

What this Trial Is About

Primary Progressive Aphasia PPA is a condition caused by various neurodegenerative disorders that mainly affect language abilities. Care for PPA patients is currently limited due to a shortage of specialists and lack of coordinated services. Researchers are evaluating a new treatment approach that combines personalized brain stimulation with language therapy to improve care in early-stage PPA. The study involves 60 patients with mild PPA who will be randomly assigned to receive either active transcranial direct current stimulation tDCS over the left dorsolateral prefrontal cortex combined with individualized language training, or placebo tDCS combined with the same language training. Treatments consist of 25-minute sessions, five days a week for two weeks. Neuroimaging and biomolecular data will be collected before and after treatment to explore how tDCS may affect the brain. Participants will undergo cognitive and language testing, neurological exams, and brain scans at the start, after treatment, and three months later. Trained neuropsychologists will conduct assessments to measure changes in naming ability, language function, quality of life, dementia severity, behavior, and molecular biomarkers. This study aims to determine the effectiveness of combining tDCS with language therapy for improving symptoms in PPA over time.

A Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia, MAINSTREAM ID:3430931