Study of Genetic and Imaging Factors in Adults with Intracranial Aneurysms Linked to the French Registry

What this Trial Is About

Researchers are collecting detailed data and human samples linked to the French Intracranial Aneurysm Registry to improve understanding and management of intracranial aneurysms ICA. The study aims to better classify ICA cases by combining genetic, imaging, and rupture information. This approach may help identify specific subgroups for improved diagnosis and risk assessment in both familial and general populations. Participants include adults with confirmed typical bifurcation ICAs verified by MRI or cerebral arteriography. The study gathers genetic mutation data, imaging of aneurysm and vascular structures, and clinical information. Blood or saliva samples are collected to support this data collection. The study includes both sporadic cases and families with multiple affected members, with screening using MRI and Time of Flight sequences. Participants will undergo imaging assessments and provide biological samples, with data collected over 36 months to develop a predictive model for ICA subtypes. Researchers will study arterial bifurcations, aneurysm characteristics, genetic mutations, and genotype-phenotype relationships. The study includes consent procedures and ensures participants are covered by social security. Safety monitoring excludes those with MRI contraindications, and participation involves ongoing data collection and evaluation.

Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms