Actively Recruiting
Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms
Led by Nantes University Hospital · Updated on 2026-05-05
1100
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
Sponsors
N
Nantes University Hospital
Lead Sponsor
F
Federation of Medical Specialties
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the bCAN study is to create a prospective collection of multimodal data and human samples, linked to the French Intracranial Aneurysm Registry (FRAN). The aim of bCAN is to enable risk stratification of ruptured ICAs by redefining "intracranial aneurysm disease". The description of genotypically and phenotypically specific subgroups of cases will pave the way for improved patient management based on new diagnostic/prognostic strategies among AIC carriers, either in a familial context, or at the level of the general population.
CONDITIONS
Official Title
Multimodal Biocollection Linked to the French Register of Intracranial Aneurysms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Any adult patient consulting for a definite and typical bifurcation intracranial aneurysm authenticated on MRI and/or cerebral arteriography
- Aneurysm discovered less than a year ago, with initial imaging (MRI and/or CTA and DSA) available
- Written consent obtained for study participation
- Patient covered by a social security plan
- Index case: Any adult patient consulting for a definite and typical bifurcation intracranial aneurysm presenting at least one other related case detected by MRI with at least one Time of Flight (TOF) sequence
- Family relatives: children, parents, brothers, sisters, of legal age, with a family history of definite, typical bifurcation intracranial aneurysm (four or more affected), screening by MRI with at least a TOF sequence
- Written consent to participate in the study
- Patient and relatives covered by a social security plan
You will not qualify if you...
- Syndromic diagnoses known to cause intracranial aneurysms: Marfan syndrome, OSA with SMAD 3, Ehlers-Danlos syndrome type II and IV, Autosomal Dominant Cystic Fibrosis, Moya-Moya syndrome
- Aneurysms that are dissecting, fusiform, associated with arteriovenous malformation, blister-like, or mycotic
- Cerebral white matter pathology on MRI suggesting Col4a1 mutation
- Patient under guardianship or conservatorship
- Person under court protection
- Contraindication to an MRI scan
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Nantes University Hospital
Nantes, Loire-Atlantique, France, 44093
Actively Recruiting
2
CHU Clermont-Ferrand
Clermont-Ferrand, France, 63000
Actively Recruiting
Research Team
R
Romain BOURCIER, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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