Actively Recruiting
Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD
Led by Johns Hopkins University · Updated on 2025-10-16
30
Participants Needed
1
Research Sites
404 weeks
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for attention-deficit/hyperactivity disorder (ADHD). The overall objective of this study is to measure the changes in task-related neural activity related to symptoms of ADHD (measured by functional MRI) and brain glutamate levels (measured by magnetic resonance spectroscopy, MRS) after treatment with methylphenidate (MPH). This will be a double-blind crossover of methylphenidate and placebo in adults with ADHD. Participants will complete neuropsychological testing along with fMRI and MRS scans after a single dose of each treatment.
CONDITIONS
Official Title
Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Right handed
You will not qualify if you...
- Pregnant or breast feeding
- Past or current neurological disorder
- Non-ADHD cause of cognitive impairment
- Uncontrolled medical disorder
- Head trauma with loss of consciousness in the last year or any functional impairment after head trauma
- Adverse reaction to methylphenidate or other stimulant medication
- Contraindication to MRI
- Current smoking
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Johns Hopkins School of Medicine
Baltimore, Maryland, United States, 21205
Actively Recruiting
Research Team
K
Kristin L Bigos, PhD
CONTACT
R
Robyn Wiseman, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here