Multi-Ethnic Study of Atherosclerosis: Relationship between Left Ventricular Shape at Cardiac MRI and 10-year Outcomes.
Charlène A Mauger, Kathleen Gilbert, Avan Suinesiaputra...
https://pubmed.ncbi.nlm.nih.gov/36125376Actively Recruiting
Age: 20Years +
All Genders
Healthy Volunteers
ID06906042
Multimodal Cardiovascular and Hepatic Population Imaging
Led by Institut National de la Santé Et de la Recherche Médicale, France · Updated on 2026-01-23
2400
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a large observational study to improve understanding of heart and liver health using advanced imaging techniques. The study focuses on healthy volunteers aged 20 and older without known cardiovascular or liver disease. It aims to reduce remaining health risks by analyzing factors like age, sex, genetics, and environment through detailed imaging and health data. Participants will undergo non-invasive imaging exams including cardiovascular MRI, hepatic MRI, hepatic ultrasound, and echocardiography with ECG. Additional tests include blood samples for metabolic profiling and biobanking, urinary pregnancy tests for women of childbearing age, and measurements of aging markers using a specialized device. The study will stratify 2400 volunteers by age and sex to gather detailed imaging and biological data. During the study, participants will have medical and paramedical examinations reviewing risk factors, medical history, and medication use. Researchers will establish reference nomograms accounting for age and sex in heart, liver, and adipose tissue. The study includes 36 months of analysis following 60 months of participant inclusion, with a focus on advanced imaging profiling and genetic risk marker identification. Participation involves regular assessments and non-invasive tests to provide detailed health insights.
CONDITIONS
Brief Title
Multimodal Cardiovascular and Hepatic Population Imaging
Who Can Participate
Age: 20Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Participation in the Constances cohort
- Age 20 years or older
- No overt cardiovascular or liver disease or related symptoms
- No known family or personal genetic disease
- Affiliation with a social security scheme or beneficiary of such a scheme
- Agreement to sign the consent form
You will not qualify if you...
- Renal function impairment with GFR less than 60 mL/min/1.73m2
- Deprived of liberty or under legal protection measures (guardianship or trusteeship)
- Contraindications to MRI such as claustrophobia or presence of metallic elements
- Pregnant or breastfeeding women (pregnancy urinary test required before inclusion for women of childbearing age)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo cardiovascular MRI, hepatic MRI, hepatic ultrasound, echocardiography including 12-lead digital ECG, and paramedical examinations such as urinary pregnancy test for women of childbearing age, blood samples for cardiometabolism profiling and biobanking, impedancemetry, and non-invasive AGE reader measurements.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 96 months
Participants are observed over time to establish reference nomograms and advanced imaging and biological profiling related to heart, liver, and adipose tissue.
No scheduled visits; data collected during analysis phase
Trial Site Locations
Total: 1 location
1
Hôpital Pitié-Salpêtrière
Paris, France
Actively Recruiting
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Research Team
A
Alban M Redheuil, PU-PH
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Chao Nie, Yan Li, Rui Li...
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Stephane Laurent, Pierre Boutouyrie, Pedro Guimarães Cunha...
https://pubmed.ncbi.nlm.nih.gov/31203728