Superficial Parasternal Intercostal Plane Block and Full Sternotomy; A Randomized Trial.
Antti Kalli, Julia Vistbacka, Eeva Moilanen...
https://pubmed.ncbi.nlm.nih.gov/40627369Actively Recruiting
Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID07587320
Effect of Induction-Time Multimodal Fascial Plane Block on Postoperative Analgesia and Opioid Consumption in Patients Undergoing Isolated Coronary Artery Bypass Grafting: A Prospective Randomized Controlled Trial
Led by Saglik Bilimleri Universitesi · Updated on 2026-05-14
56
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative pain after coronary artery bypass grafting (CABG) through median sternotomy is a significant issue linked to increased opioid use and complications. Researchers are evaluating whether a multimodal fascial plane block package, including bilateral superficial parasternal block, bilateral serratus anterior plane block, and adductor canal block, can improve pain control and reduce opioid consumption in patients undergoing elective isolated CABG with saphenous vein graft harvesting. In this randomized controlled trial, adult patients aged 18 to 80 years scheduled for elective isolated CABG will be assigned to one of two groups. One group will receive the multimodal fascial plane block package following induction of general anesthesia and before surgical incision, along with standard perioperative analgesia. The other group will receive standard perioperative and postoperative analgesia without regional blocks. All other care will be standardized. Participants will be monitored for total opioid consumption within the first 48 hours after surgery, pain scores at 6, 12, 24, and 48 hours, time to first opioid requirement, extubation time, and incidence of postoperative pulmonary complications and atrial fibrillation. Lengths of ICU and hospital stay and time to first mobilization will also be recorded. The study aims to assess whether this multimodal block approach improves postoperative analgesia and clinical outcomes after CABG surgery.
CONDITIONS
Brief Title
Multimodal Fascial Plane Block for Postoperative Analgesia in Isolated CABG Surgery
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- Scheduled for elective isolated coronary artery bypass grafting (CABG) with saphenous vein graft harvesting
- ASA physical status II-IV
- Ability to provide written informed consent
You will not qualify if you...
- Known coagulopathy or contraindication to regional anesthesia
- Use of anticoagulant therapy precluding regional block
- Known allergy to local anesthetics
- Local infection at planned block sites
- Chronic opioid use or chronic pain syndrome
- Emergency surgery
- Redo sternotomy
- Severe neurological disorder affecting pain assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Treatment
Duration - Surgery day with immediate perioperative period
Participants undergo coronary artery bypass grafting surgery and receive either a multimodal fascial plane block package after induction of general anesthesia and before surgical incision, or standard perioperative analgesia without regional block.
1 surgical and anesthesia visit (in-person)
Post-operative Follow-up
Duration - 48 hours after surgery
Participants are monitored for pain intensity, opioid consumption, extubation time, and recovery outcomes during the first 48 hours after surgery.
Multiple assessments at 6, 12, 24, and 48 hours after surgery
Trial Site Locations
Total: 1 location
1
University of Health Sciences, Diyarbakir Gazi Yasargil Training and Research Hospital
Diyarbakır, Diyarbakır, Turkey (Türkiye)
Actively Recruiting
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Research Team
S
Selen Topalel, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Ultrasound-Guided Continuous Parasternal Intercostal Block Relieves Postoperative Pain After Open Cardiac Surgery: A Case Series.
Junhua Zhang, Fuchao Luo, Xiaoliang Zhang...
https://pubmed.ncbi.nlm.nih.gov/34183252The analgesic effects of combined bilateral parasternal block and serratus anterior plane block for coronary artery bypass grafting surgery.
Emine Nilgün Zengin, Hülya Yiğit, Muhammed Çobas...
https://pubmed.ncbi.nlm.nih.gov/39103782