Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
NCT06449326

Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms

Led by University of New Mexico · Updated on 2025-07-02

64

Participants Needed

2

Research Sites

173 weeks

Total Duration

On this page

Sponsors

U

University of New Mexico

Lead Sponsor

N

New Mexico VA Healthcare System

Collaborating Sponsor

AI-Summary

What this Trial Is About

MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress disorder (PTSD) in a comorbid Veteran population.

CONDITIONS

Official Title

Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 18 to 80 years
  • Diagnosed with PTSD and have ongoing symptoms with a PCL-5 score of 31 or higher
  • Fluent in English
  • On stable doses of psychotropic medications for at least one month
Not Eligible

You will not qualify if you...

  • History of neurological disease beyond mild traumatic brain injury
  • History of seizures other than immediate posttraumatic or childhood febrile seizures
  • History of psychotic disorders such as schizophrenia or bipolar disorder
  • Active substance or alcohol dependence without ongoing treatment
  • Presence of any implanted electrical device such as a pacemaker
  • Recent medical hospitalization within the past four weeks
  • Any condition preventing completion of the study protocol
  • Unable to provide informed consent or has a legal representative
  • Involved in ongoing litigation related to PTSD, TBI, disability, or service connection
  • Contraindication to MRI
  • Pregnant women
  • Members of vulnerable populations including minors and prisoners
  • Cognitively impaired adults lacking capacity to consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

UNM Center for Psychiatric Research

Albuquerque, New Mexico, United States, 87106

Actively Recruiting

2

New Mexico VA Health Care System

Albuquerque, New Mexico, United States, 87108

Actively Recruiting

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Research Team

D

Davin Quinn, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms | DecenTrialz