Study on How Probiotics May Improve REM Sleep Behavior Disorder in Parkinsons Disease Using Advanced Brain Imaging

What this Trial Is About

Researchers are investigating how probiotics might improve rapid eye movement sleep behavior disorder RBD, a non-movement symptom and risk factor of Parkinsons disease PD. This study focuses on patients with PD-related RBD, idiopathic RBD, and healthy controls, using advanced imaging and clinical assessments to understand the effects and mechanisms of probiotic treatment on RBD and PD motor symptoms. Participants receive probiotic treatments involving Bifidobacterium triple viable capsules and Bacillus licheniformis capsules. Some groups maintain their original anti-Parkinsons medications while taking probiotics. The study includes monitoring before and after treatment using multimodal imaging techniques like resting-state functional MRI, proton magnetic resonance spectroscopy, and 123I-MIBG cardiac scintigraphy, along with clinical symptom scales and microbiota analysis. During the 12-week study, participants undergo evaluations including clinical scales for movement and sleep behavior, polysomnography for sleep disorders, blood and stool tests for metabolites and bacteria abundance, and multiple imaging scans. Researchers analyze these data to explore probiotic impact on brain structure, function, and gut microbiota. Safety and symptom changes are monitored throughout, with the trial concluding after the treatment and assessment period.

Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving RBD with Parkinson's Disease