Actively Recruiting
Multimodal Imaging Assessment After Revascularization in Patients With Acute Myocardial Infarction
Led by The Affiliated Hospital of Qingdao University · Updated on 2025-08-19
20
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of 18F-Pentixafor PET/MR imaging in patients who have experienced their first acute myocardial infarction (AMI) and undergone interventional procedures such as percutaneous coronary intervention (PCI) or balloon angioplasty. The study aims to assess coronary microcirculatory function, cardiac function, myocardial viability, inflammatory response, and the effectiveness of these interventions. It also plans to perform risk stratification and prognostic analysis for these patients. The study will enroll 20 patients and involve several procedures including patient screening, informed consent, baseline assessments like medical history, laboratory tests, ECGs, and the specialized 18F-Pentixafor PET/MR examination. Imaging results will be reviewed by expert physicians from Radiology and Nuclear Medicine. Baseline cardiac magnetic resonance (CMR) exams will be done within 7 days after PCI, with follow-up CMR at 6 months post-procedure to monitor changes over time. Participants will undergo various evaluations such as blood and urine tests, blood biochemistry, ECG, and imaging studies. The main outcomes measured include myocardial uptake of 18F-Pentixafor, left ventricular ejection fraction (LVEF), and infarct characterization by PET and MRI imaging. Secondary outcomes include myocardial T1 and T2 values, extracellular volume, and strain analysis. The study will monitor patients from baseline through 6 months, aiming to provide detailed insights into heart function and recovery after AMI treatments.
CONDITIONS
Brief Title
Multimodal Imaging Assessment After Revascularization in Patients With Acute Myocardial Infarction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a clinical diagnosis of first-episode acute myocardial infarction (AMI) who underwent emergency percutaneous coronary intervention (PCI).
- Patients must have complete baseline clinical data.
- Baseline cardiac magnetic resonance (CMR) examinations performed within 7 days post-PCI.
- Follow-up CMR completed at 6 months post-procedure.
You will not qualify if you...
- Patients with severe cardiac decompensation (Killip class 4) or clinically unstable conditions.
- Patients with valvular heart disease, congenital heart disease, pulmonary hypertension, cardiomyopathy, or persistent atrial fibrillation that affect cardiac assessments.
- Prior history of myocardial infarction or coronary revascularization (PCI/CABG).
- Severe systemic diseases including hematologic disorders, malignancies, rheumatic/autoimmune diseases, or severe hepatic/renal failure.
- Contraindications to cardiac magnetic resonance imaging (e.g., claustrophobia, pacemaker).
- Pregnant or breastfeeding women, or women of childbearing potential without effective contraception.
- Sexually active individuals of reproductive age unwilling to use reliable contraception.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Within 1 week after enrollment
Participants undergo baseline cardiac magnetic resonance (CMR) examinations and PET imaging to assess myocardial uptake, left ventricular function, and infarct characterization.
1 visit (in-person)
Duration - 6 months
Participants complete follow-up cardiac magnetic resonance (CMR) imaging at 6 months post-procedure to monitor cardiac function and recovery.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China, 266003
Actively Recruiting
Research Team
P
Pei Nie, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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