Actively Recruiting
Multimodal MRI for MRgFUS Central Lateral Thalamotomy in Neuropathic Pain
Led by Chinese PLA General Hospital · Updated on 2021-11-16
12
Participants Needed
1
Research Sites
241 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To explore the pathogenesis underlying neuropathic pain as well as the mechanisms of pain relief after Magnetic resonance-guided focused ultrasound (MRgFUS) Central Lateral Thalamotomy through multi-model MRI study, and to identify imaging biomarkers for triaging patients and predicting the clinical outcomes. Craniofacial neuropathic pain is one of the most serious debilitating symptoms, leading to emotional disorders and poor quality of life. Previous studies have shown that Magnetic resonance-guided focused ultrasound (MRgFUS) central lateral thalamotomy is a minimally invasive and effective procedure for medication-refractory neuropathic pain patients. However, the clinical benefits were variable among individuals. It is important to clarify the pathogenesis of neuropathic pain and the mechanisms of pain relief induced by MRgFUS central lateral thalamotomy to triage suitable candidates for the procedure and predict clinical outcomes. In addition, localization precision and individualized treatment remain to be improved.
CONDITIONS
Official Title
Multimodal MRI for MRgFUS Central Lateral Thalamotomy in Neuropathic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female, aged between 18 and 75 (inclusive)
- Able and willing to participate in the study
- Chronic neuropathic pain lasting more than 6 months
- Worst Numerical Pain Rating Scale score of 5 or higher, with similar pain level for at least two months
- Medication-refractory neuropathic pain resistant to at least three types of neuropathic pain drugs and one interventional procedure
You will not qualify if you...
- Craniofacial pain syndrome linked to malignant tumors of the head and neck
- Idiopathic trigeminal neuralgia
- Headache syndromes such as migraine
- Temporomandibular joint syndrome
- Atypical facial pain or pain related to somatoform disorders
- Considered unqualified by expert evaluation
- Active mental illness
- Unstable heart condition
- Severe hypertension with diastolic blood pressure over 100 mm/Hg despite medication
- Standard MRI contraindications like non-MRI compatible implanted metal devices including pacemakers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
H
Hao-xuan Lu
CONTACT
X
Xin Lou, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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