Neuromonitoring Study During Normothermic Regional Perfusion in Organ Donors Declared Dead by Circulatory Criteria After Life Support Withdrawal

What this Trial Is About

This research aims to study organ donors who have been declared dead by circulatory criteria after withdrawal of life-sustaining measures. The goal is to confirm that cerebral blood flow and brain function do not return during normothermic regional perfusion, a process used to restore organ function after death. This study will improve understanding about the safety and adherence to death determination in these donors. Participants will undergo continuous and detailed neuromonitoring during the withdrawal of life support, the dying process, and the normothermic regional perfusion procedure. The neuromonitoring includes invasive and non-invasive methods such as intracranial pressure monitoring, oxygenation and blood flow measurements, EEG, cerebral microdialysis, transcranial Doppler, jugular bulb oximetry, near infrared spectroscopy, evoked potentials, and bispectral index monitoring. Throughout the study, monitoring will be performed starting one hour before life support withdrawal, continuing through the dying process, and for two hours during normothermic regional perfusion. Researchers will assess the absence of brain circulation and function, evaluate the feasibility of using multimodal monitoring, and compare invasive and non-invasive neuromonitoring methods. The total participation time varies depending on individual timing of withdrawal and perfusion procedures.

Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures