Actively Recruiting
Prognostic Value of Multimodal Nutritional Status and Sarcopenia Assessment for Postoperative Risk Stratification in Patients Undergoing Lung Cancer Surgery: A Prospective Cohort Study
Led by Ondokuz Mayıs University · Updated on 2026-03-30
142
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how combined assessments of nutritional status and muscle loss (sarcopenia) can predict outcomes for adults undergoing lung cancer surgery. Malnutrition and sarcopenia are known to affect recovery, but their joint impact has not been fully explored. This observational study aims to improve risk prediction and support personalized care before and after surgery for patients with primary lung cancer. Participants will have their nutritional health evaluated through blood tests for proteins and inflammatory markers, clinical nutrition scores, and physical tests like handgrip strength. Muscle loss will be measured using CT scans and ultrasound of chest muscles taken within 30 days before surgery. All patients will undergo anatomical lung resections such as lobectomy or segmentectomy, and no experimental treatments will be given as part of the study. After surgery, researchers will track complications, need for intensive care, hospital stay duration, and short-term mortality using standard grading systems. Statistical analyses will identify factors independently linked to poor outcomes and develop a combined risk model. This long-term observational study aims to provide practical tools to help tailor nutritional and rehabilitation strategies in lung cancer surgery patients.
CONDITIONS
Brief Title
Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patients undergoing anatomical lung resection (lobectomy or segmentectomy) for primary lung cancer
- Availability of preoperative thoracic computed tomography (CT) within 30 days before surgery
- Completion of preoperative nutritional assessment and ultrasonographic muscle measurements
- Ability to provide written informed consent
You will not qualify if you...
- Receipt of neoadjuvant chemotherapy, immunotherapy, or radiotherapy
- Emergency surgery
- Pneumonectomy
- Combined resection of another organ during the same procedure
- Inadequate or non-evaluable imaging or measurement data
- Immunosuppressive therapy or presence of advanced/metastatic disease
- Significant thoracic deformity or prior conditions interfering with muscle measurements
- Refusal or inability to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 30 days before surgery
Participants undergo preoperative assessments including nutritional status evaluation through laboratory measurements, clinical nutritional scores, bioimpedance analysis, handgrip strength, functional tests, and imaging-based sarcopenia assessment using CT and ultrasound.
1 to 2 visits as part of routine care
Duration - Hospital stay up to 30 days
Participants undergo anatomical lung resection surgery and receive immediate postoperative care during hospitalization.
Hospitalization period with daily monitoring
Duration - 30 days after surgery
Participants are observed for postoperative outcomes including complications, intensive care unit requirement, length of hospital stay, and short-term mortality.
Follow-up visits or assessments during 30 days post-surgery
Trial Site Locations
Total: 1 location
1
Ondokuz Mayis University Faculty of Medicine, Department of Thoracic Surgery
Samsun, Samsun, Turkey (Türkiye)
Actively Recruiting
Research Team
C
Caner İşevi, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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