Actively Recruiting
Multimodal Phenotyping in Adolescent Inpatient Depression: An Observational Study
Led by Jiangsu Province Nanjing Brain Hospital · Updated on 2025-11-25
1000
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This cohort study involves the dynamic collection of clinical information from adolescent patients with major depressive episodes (including both major depressive disorder and bipolar disorder), encompassing serum parameters, physiological-behavioral signals, neuroimaging data, and neuropsychological scales. The study aims to summarize the comprehensive clinical characteristics of this population, identify new risk factors, and establish multivariate predictive models for treatment response, cognitive and emotional impairments. Furthermore, this research will thoroughly investigate the underlying neural mechanisms linking clinical manifestations and neuroimaging features in major depressive episodes.
CONDITIONS
Official Title
Multimodal Phenotyping in Adolescent Inpatient Depression: An Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 10 and 20 years of age
- Diagnosis of major depressive disorder or bipolar disorder according to DSM-IV criteria assessed by SCID-I (≥18 years) or K-SADS-PL (<18 years)
- Current moderate to severe depressive episode defined as Hamilton Depression Rating Scale score ≥17
- Informed consent provided by participants and one or two parents for participants under 18 years old
You will not qualify if you...
- Prior treatment with repetitive transcranial magnetic stimulation, transcranial direct current stimulation, electroconvulsive therapy, or standard psychological therapy within 6 months before screening
- Comorbidity with other DSM-IV Axis I disorders or personality disorders
- Clinical judgment of serious suicide risk
- Diabetes mellitus, hypertension, vascular or infectious diseases, and other major medical comorbidities
- Unstable medical conditions such as severe asthma; neurological disorders including head injury with loss of consciousness ≥5 minutes, cerebrovascular diseases, brain tumors, or neurodegenerative diseases
- Mental retardation or autism spectrum disorder
- Contraindications to MRI such as severe claustrophobia, pacemakers, or metal implants
- Current drug or alcohol abuse or dependence
- Pregnant or lactating females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
210000
Nanjing, Jiangsu, China
Actively Recruiting
Research Team
Z
Zexin Lin
CONTACT
J
Jia Duan
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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