Physical Exercise for Psychosis: A Study Protocol Evaluating a Multimodal Physical Exercise Program for Adults Treated with Long-Acting Injectable Antipsychotics

What this Trial Is About

People with psychotic disorders like schizophrenia often face challenges in daily functioning, physical health, and quality of life. This study evaluates the feasibility and impact of a structured, multimodal physical exercise program for adults with psychosis who are treated with long-acting injectable antipsychotics. The goal is to see if supervised exercise can improve physical function, psychological well-being, and biological markers related to brain health and metabolism. Participants will be divided into two groups: one receiving usual care and the other participating in a 24-week supervised exercise program. The exercise includes aerobic activities such as walking and cycling, strength training with exercises targeting different muscle groups, and mobility, balance, and flexibility exercises. Sessions are conducted by qualified professionals in an outpatient psychiatric setting in Portugal. Throughout the study, participants will undergo assessments at baseline, during the program, after completion, and at an 8-week follow-up. These assessments measure physical function, body composition, psychological well-being, quality of life, and blood markers like brain-derived neurotrophic factor, dopamine, serotonin, and metabolic indicators. The study aims to provide evidence for including exercise as part of routine psychiatric care for people with psychosis.

Multimodal Physical Exercise Program (Physical Exercise for Psychosis) for People With Psychosis Treated With Long-Acting Injectable Antipsychotics