Study of a 16-Week Multimodal Prehabilitation Program During and After Chemotherapy for Patients With Colorectal Liver Metastases Awaiting Surgery

What this Trial Is About

Researchers are studying patients with colorectal liver metastases CRLM to see if a 16-week multimodal prehabilitation program MPP given during chemotherapy and recovery before liver surgery can improve physical fitness more than a 4-week program given only after chemotherapy. Liver resection is the only curative option for CRLM, but chemotherapy reduces physical capacity. This study aims to find better ways to help patients regain fitness before surgery through a structured program. The MPP includes in-hospital high to moderate intensity exercise, nutrition assessment with high-protein supplements, smoking cessation support, psychological help, and a comprehensive geriatric assessment. Two groups will be compared one receiving the program during 12 weeks of chemotherapy plus 4 weeks before surgery, and another starting the program only in the 4 weeks after chemotherapy until surgery. Participants will be assessed using the six-minute walk test 6MWT at several points including before chemotherapy, after chemotherapy, before surgery, and postoperatively up to one year. Other measures include quality of life, postoperative complications, hospital stay length, readmission rates, functional capacity tests, psychological health, and nutritional status. The study will monitor all interventions to check feasibility and safety throughout the trial period ending one year after surgery.

Multimodal Prehabilitation During Chemotherapy in Patients With Colorectal Liver Metastases