Multimodal Prehabilitation Program Combining Exercise, Nutrition, and Psychological Support During Chemotherapy for Early Breast Cancer

What this Trial Is About

Researchers are evaluating whether a multimodal prehabilitation program that includes physical exercise, nutritional support, and psychological intervention during neoadjuvant chemotherapy can improve the pathological response in women with non-metastatic breast cancer. This study focuses on early breast cancer patients who are candidates for chemotherapy before surgery and aims to compare the treatment response and recovery between those receiving the prehabilitation program and those under standard care. Participants will be randomly assigned to one of two groups an intervention group receiving the multimodal prehabilitation program during chemotherapy for 4 to 6 months, and a control group receiving standard clinical management without prehabilitation. The prehabilitation program involves structured physical exercise sessions twice a week, psychological therapies such as mindfulness or anxiety management, and nutritional counseling tailored to each patients needs. Throughout the study, participants will be assessed at baseline, after chemotherapy, and following surgery to evaluate physical, psychological, and nutritional status, as well as changes in the tumor microenvironment. The main outcome measured is the pathological response to chemotherapy using the Residual Cancer Burden index. Secondary outcomes include treatment tolerance, quality of life, postoperative recovery, and various health and tumor-related assessments over up to one year after surgery.

Multimodal Prehabilitation Program That Combines Physical Exercise, Psychological Intervention and Nutritional Support to Improve the Response to Neoadjuvant Chemoterhapy in Early Breast Cancer Patients