Actively Recruiting
Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics
Led by University of Minnesota · Updated on 2025-07-14
100
Participants Needed
2
Research Sites
251 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Tourette Syndrome and Persistent Motor/Vocal Tic Disorder affect 1-3% of youth and can be associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, and peer victimization. Chronic tics are the primary symptom. Comprehensive Behavioral Intervention for Tics (CBIT) is a manualized treatment focused on tic management skills. During the core CBIT procedure, competing response training, patients learn to inhibit tics by engaging in a competing motor action. The overall objective of this study is to identify bio-behavioral predictors and correlates of response and the most potent aspects of CBIT. Participants with chronic tics will complete a manualized course of 8-session CBIT. Neural, behavioral, psychosocial, and global functioning will be assessed longitudinally to examine predictors and correlates of response. CBIT sessions will be video recorded. CBIT process will be measured with a video-based behavioral coding scheme that will be refined and validated during years 1-2 using archival CBIT videos
CONDITIONS
Official Title
Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 10-17 years at time of enrollment.
- Current chronic motor and/or vocal tics for at least 1 year without a tic-free period longer than 3 consecutive months.
- Tics not caused by a medical condition or substance effects.
- At least moderate tic severity: Yale Global Tic Severity Scale total score 64 (or 69 for motor or vocal tics only).
- Full scale IQ greater than 70.
- Child must be fluent in English to understand study instructions.
- Participants on stable psychotropic medications for at least 6 weeks, expected to remain stable during the study.
- Participants receiving non-tic related psychotherapy overlapping with CBIT must stop therapy upon enrollment until post-treatment assessment.
- All concurrent treatments will be monitored.
You will not qualify if you...
- Unable to undergo MRI or EEG (e.g., metal in body, claustrophobia, orthodontia).
- Active suicidal thoughts.
- Previous diagnosis of psychosis, cognitive disability, or structural brain disease impeding participation.
- History of seizure disorder.
- Active substance abuse or dependence.
- Other psychiatric or medical conditions requiring immediate treatment or making delay inappropriate.
- Concurrent psychotherapy focused on tics or overlapping with CBIT.
- Psychotropic medication changes within past 6 weeks or planned changes during study.
- Four or more previous CBIT sessions.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University of California
San Diego, California, United States, 92093
Actively Recruiting
2
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
S
Sonya Wang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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