Multimodal Study of Pediatric Behavioral Treatment for Tourette and Persistent Tic Disorders Using Comprehensive Behavioral Intervention for Tics CBIT with Brain and Behavioral Assessments

What this Trial Is About

This research focuses on children and adolescents aged 10 to 17 years with Tourette Syndrome or Persistent MotorVocal Tic Disorder, conditions characterized by chronic tics that can impact daily functioning, emotional well-being, and quality of life. The study aims to understand the bio-behavioral factors that predict and relate to how well patients respond to Comprehensive Behavioral Intervention for Tics CBIT, a specialized therapy designed to help manage tics. Participants will undergo an 8-session CBIT program delivered weekly over 10 weeks. CBIT includes psychoeducation about tics, functional interventions, competing response training to inhibit tics, social support, motivational enhancements, and homework assignments involving self-monitoring and practice. All sessions will be video recorded and analyzed to refine the understanding of the most effective elements of the therapy. Throughout the study, participants will be assessed at multiple points including neural, behavioral, psychosocial, and global functioning measures. Researchers will track changes in tic severity using the Yale Global Tic Severity Scale and evaluate brain connectivity through resting-state fMRI. Quality of life and therapy process components will also be measured. Participants will complete daily homework logs, and their progress will be monitored over about 27 weeks to identify factors linked to successful treatment response.

Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics