Actively Recruiting
A Multimodal Prospective Cohort Study of Parkinsonism
Led by Ruijin Hospital · Updated on 2026-04-28
640
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach. The study plans to enroll 400 patients with Parkinsonism, 120 patients with rapid eye movement sleep behavior disorder, and 120 healthy controls, with follow-up for 5 years. Assessments will include neuroimaging, clinical rating scales, biological samples, blood flow evaluation, neurophysiological testing, tremor analysis, and voice and video assessments. The study aims to characterize disease progression, explore factors associated with progression from rapid eye movement sleep behavior disorder to Parkinsonism, and improve the ability to distinguish among different Parkinsonian disorders.
CONDITIONS
Official Title
A Multimodal Prospective Cohort Study of Parkinsonism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meets diagnostic criteria for rapid eye movement sleep behavior disorder established by the American Academy of Sleep Medicine (for REM sleep behavior disorder participants)
- Meets diagnostic criteria for Parkinsonism established by the International Parkinson and Movement Disorder Society (for Parkinsonism participants)
- Chinese citizen
- Age over 30 years and under 80 years
- Able to understand the study, show good compliance, and provide written informed consent personally or through a legal representative
- No neurodegenerative disease, no history of head trauma or head surgery, no history of stroke, epilepsy, tumor, or psychiatric disease (for healthy controls)
- No metal implants or cardiac pacemaker (for healthy controls)
- No severe chronic disease or severe hepatic or renal insufficiency (for healthy controls)
- Education level of primary school or above (for healthy controls)
You will not qualify if you...
- Significant cognitive impairment (MMSE ≤23)
- Unable to sign the informed consent form or unable to complete study procedures for other reasons
- Any other condition that, in the opinion of the investigator, makes the participant unsuitable for this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China, 200025
Actively Recruiting
Research Team
J
Jun Liu, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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