Actively Recruiting
Multimodality Cardiac Imaging for Disease Progression in ATTR-CM
Led by Dominik Benz · Updated on 2025-12-09
50
Participants Needed
1
Research Sites
84 weeks
Total Duration
On this page
Sponsors
D
Dominik Benz
Lead Sponsor
O
Olga Mayenfisch Stiftung, Zurich, Switzerland
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate whether new imaging techniques can help us to better understand the cardiac amyloidosis. The disease can be slowed down with various medications (e.g., tafamidis, acoramidis, or vutrisiran). However, treatment is not effective in all patients-in about one-third of cases, the disease continues to progress. So far, we know little about the exact causes of this and what biological changes occur in the heart muscle. The main question it aims to answer is: Will new imaging techniques help us understand the course of the cardiac amyloidosis? Participants will have additional examinations: * At the beginning of the study: one additional heart ultrasound examination, one cardiac MRI and one cardiac PET, blood examination during the regular examination, questionnaires. * After a year: one additional heart ultrasound examination, one cardiac MRI and one cardiac PET, blood examination during the regular examination. Time required: * Heart ultrasound examination: 5-10 Minutes * Cardiac MRI: 2 hours * Cardiac PET: 2 hours * Questionnaires: 5-10 Minutes.
CONDITIONS
Official Title
Multimodality Cardiac Imaging for Disease Progression in ATTR-CM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with cardiac ATTR amyloidosis, as recently defined by multi-societal criteria, who are about to start tafamidis at the University Hospital Zurich
You will not qualify if you...
- Any other disease-modifying therapy (e.g. patisiran)
- Ongoing supraventricular arrhythmia
- Ventricular pacing
- Prior septal myocardial infarction
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University Hospital Zurich
Zurich, Canton of Zurich, Switzerland, 8091
Actively Recruiting
Research Team
D
Dominik C Benz, PD Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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