Actively Recruiting
Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2026-01-22
400
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
Sponsors
I
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lead Sponsor
U
University of Bologna
Collaborating Sponsor
AI-Summary
What this Trial Is About
The present study is a single-centre prospective study that will enrol pregnant women during their first trimester of pregnancy (11+0 - 13+6 weeks of gestation). During pregnancy, women will undergo standard clinical evaluation and management. During the two study visits (enrollment and 24+0 - 27+6 weeks of gestation) the investigators will perform arterial tonometry (Pulsepen) and in vivo darkfield microscopy (Glycocheck) to evaluate endothelial and vascular function. A urine sample and a blood sample for specific study analyses on metabolic profile, endothelial and angiogenic markers will be collected. Pregnancy outcomes will be collected at delivery and five years after delivery all the participants will be interview to collect long-term cardiovascular outcomes. Serum endothelial and angiogenic markers will be evaluated only in participants who will develop hypertensive disorders of pregnancy and in an equal number of controls matched for age and body mass index at the time of conception.
CONDITIONS
Official Title
Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than or equal to 18 years
- Single pregnancy
- No previous pregnancies lasting more than 12 weeks
- Willing and able to give informed consent for participation in the study
You will not qualify if you...
- Intermediate-high risk of genetic abnormalities or need for invasive prenatal tests (amniocentesis, villocentesis)
- History of solid organ or hematopoietic stem cell transplantation
- Chronic renal failure (eGFR 64; 45 ml/min/1.73 m2)
- Chronic treatment with antihypertensive drugs and/or xanthine oxidase inhibitors
AI-Screening
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Trial Site Locations
Total: 1 location
1
Cardiovascular Internal Medicine Unit, IRCCS University Hospital of Bologna, Bologna, Italy
Bologna, Italy, 40124
Actively Recruiting
Research Team
A
Arrigo Francesco Giuseppe Cicero, MD, PhD
CONTACT
C
Cristina Scollo, BD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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