Multiparametric Imaging-based Intraoperative Navigation for Guidance of Surgical Resection and Postoperative Radiotherapy in Patients With Head-and-neck Tumors - NAVIGATORR

What this Trial Is About

Researchers are evaluating a new approach to improve local tumor control in patients with head and neck cancer, specifically focusing on tumors of the midface, upper jaw, and skull base. The study aims to enhance the precision of surgical tumor removal and personalize radiotherapy plans. This trial addresses the current stagnation in surgical oncology for head and neck cancers by integrating advanced imaging and navigation techniques during surgery, supported by interdisciplinary collaboration among surgeons, pathologists, and radiation oncologists. The study involves 60 patients who will undergo surgery guided by intraoperative navigation and the creation of detailed tumor resection maps. These maps accurately mark tumor margins and potential residual tumor areas and are combined with histopathological information. The 3D resection maps are then used in radiotherapy planning to tailor postoperative treatment. This multidisciplinary workflow is designed to achieve clear surgical margins and improve treatment outcomes. Participants will be closely monitored for safety within 24 months after radiotherapy, with primary focus on the safety of tumor resection. Researchers will also assess local tumor control and overall survival, comparing results to existing literature. Data exchange among the clinical teams supports personalized care. The study requires patients to consent, be medically operable, and have an expected need for postoperative radiotherapy. Total participation includes surgery and long-term follow-up assessments.

Multiparametric Imaging-based Intraoperative Navigation for Guidance of Surgical Resection and Postoperative Radiotherapy in Patients With Head-and-neck Tumors