Actively Recruiting
Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
Led by University of Rochester · Updated on 2026-04-08
200
Participants Needed
1
Research Sites
124 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test the extent to which different treatment components work to improve pediatric post-traumatic stress disorder (PTSD). It will also provide evidence for how these components work. The main research questions are: What are the effects of different components used to treat PTSD? What do these components change to produce benefits in PTSD? Researchers will: Compare components to a psychological placebo to estimate their effects and measure how they work Examine how components work alone and in conjunction with other components Participants will: Receive different combinations of components and placebo Attend weekly treatment sessions Provide information to evaluate changes in PTSD
CONDITIONS
Official Title
Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A child aged 8 to 17 years exposed to at least one DSM-defined trauma
- Child assent to participate
- Participation of a caregiver with custodial rights to provide permission
- Willingness to participate in treatment sessions and complete surveys
- Meets PTSD diagnostic criteria resulting from identified trauma exposure
- Ability to read and understand English
- Agreement to be randomized to a treatment group
- Stable caregiving environment for at least two months without planned transition
- Stable use of psychotropic medications without dose changes for two months prior to study
- Caregiver or child owns a smartphone capable of downloading a study app
You will not qualify if you...
- Psychiatric conditions requiring higher level care (e.g., suicidal intent, psychotic disorder)
- Intelligence quotient (IQ) less than 70
- Currently receiving behavioral health treatment for PTSD or pediatric trauma
- Caregiver who is a perpetrator of any identified trauma (e.g., sexual abuse)
- Contraindications for MRI (e.g., metal in the body)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Mt. Hope Family Center
Rochester, New York, United States, 14608
Actively Recruiting
Research Team
C
Chad E Shenk, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
16
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