Feasibility Study of Online Social Management Training for Adults Aged 16 to 65 with Sex Chromosome Aneuploidies

What this Trial Is About

This research aims to evaluate Social Management Training SMT, a 10-session group-based psychosocial intervention, for adults aged 16 to 65 with sex chromosome aneuploidies SCAs. The study focuses on assessing whether SMT can improve mental health as the primary outcome, along with secondary outcomes related to executive functions and autism symptoms. The intervention builds on previous work with men with Klinefelter syndrome and adapts SMT to a digital format to reach a wider Norwegian population with various SCAs. Participants will take part in 10 group sessions delivered online, covering topics such as social information processing, emotion regulation, executive functions, and individual learning goals. The study uses a single-group multiple baseline design with measurements collected at six time points three before and three after the intervention, spanning 30 weeks. This design allows comparison of outcomes before and after SMT to examine feasibility, acceptability, and potential benefits. During the study, participants will complete questionnaires measuring mental health, social responsiveness, and executive function multiple times before and after the intervention. The Symptom Checklist 25 SCL-25 is the primary tool for mental health assessment, while the Social Responsiveness Scale and Behavior Rating Inventory of Executive Function are secondary measures. The study will monitor participants throughout the 30-week period and aims to include 20-30 adults with genetically confirmed SCAs.

A Multiple Baseline Feasibility Trial of Social Management Training for People With Sex Chromosome Aneuploidies