Actively Recruiting
Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction
Led by Erasmus Medical Center · Updated on 2025-01-21
200
Participants Needed
6
Research Sites
196 weeks
Total Duration
On this page
Sponsors
E
Erasmus Medical Center
Lead Sponsor
I
Ikazia Hospital, Rotterdam
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective is to investigate the association between temporal evolutions of blood biomarkers and clinical adverse events, in order to produce a dynamic, individual, and accurate prediction model for patients with HFpEF. Moreover several secondary objectives will be investigated.
CONDITIONS
Official Title
Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age of 18 years or older
- Capable of understanding and signing informed consent
- Diagnosis of HFpEF according to the HFA-PEFF diagnostic algorithm of the ESC or a high (90%) probability of HFpEF according to the H2FPEF score (score of 6 or higher)
You will not qualify if you...
- History of left ventricular ejection fraction (LVEF) 40% or lower
- Scheduled for surgery or intervention for coronary or non-coronary indications within 6 months of inclusion
- Impaired renal function defined as eGFR less than 20 mL/min/1.73 m2 or requiring dialysis at screening
- Acute or chronic liver disease with serum transaminases or alkaline phosphatase more than three times the upper limit of normal at screening
- COPD Gold stage IV
- Congenital heart disease
- Pregnancy
- Coexisting condition with life expectancy less than 1 year
- Unlikely to attend all scheduled follow-up visits
- Linguistic barrier
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Noordwest Ziekenhuisgroep
Alkmaar, North Holland, Netherlands, 1815JD
Actively Recruiting
2
Amsterdam UMC
Amsterdam, North Holland, Netherlands, 1081HV
Actively Recruiting
3
OLVG Ziekenhuis
Amsterdam, North Holland, Netherlands, 1091AC
Actively Recruiting
4
Franciscus Gasthuis & Vlietland Ziekenhuis
Rotterdam, South Holland, Netherlands, 3004BA
Actively Recruiting
5
Erasmus MC
Rotterdam, South Holland, Netherlands, 3015GD
Actively Recruiting
6
Ikazia Ziekenhuis
Rotterdam, South Holland, Netherlands, 3083AN
Actively Recruiting
Research Team
I
Isabella Kardys, Prof.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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