Actively Recruiting
Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder
Led by University of Minnesota · Updated on 2026-05-08
60
Participants Needed
1
Research Sites
448 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sixty patients will be enrolled in this study who are treated for Parkinson's disease (PD) with bilateral deep brain stimulation of subthalamic nucleus (STN) or globus pallidus (GP), who have a pre- operative 7 Tesla MRI including diffusion tensor imaging for tractography and a postoperative head CT for electrode localization, and in whom at least 3 months have passed since activation of their neurostimulators, for stabilization of clinical stimulator settings. Using their MRI and CT, the investigators will construct patient-specific models of electrical current spread to neuroanatomical tar- gets surrounding the electrode. Then applying nonlinear (particle swarm) optimization, patient- specific stimulator settings will be designed to maximally or minimally activate specific path- ways. In STN DBS: pedunculopallidal vs. pallidopeduncular pathways. In GP DBS: pallidopeduncular pathways at its origin in GP pars interna (GPi) vs. inhibitory afferents to GPi (from GP pars externa GPe). All stimulation falls within the the FDA-approved range for DBS for PD.
CONDITIONS
Official Title
Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Parkinson's disease
- Bilateral deep brain stimulation (DBS)
- Directional DBS electrode system
- Preoperative MRI at least 7 Tesla with diffusion tensor imaging
- Postoperative head CT with 1mm cuts
- At least 3 months since initial activation of the neurostimulator
You will not qualify if you...
- Neurological or musculoskeletal disorders significantly affecting gait, balance, or limb movements
- Dementia
- Prior stereotactic neurosurgery other than DBS for movement disorder
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
J
Johanna Caskey, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
NA
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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