What this Trial Is About

Multiple sclerosis (MS) is a neurological disease caused by inflammation and immune system problems, influenced by both genetic and environmental factors. Researchers are studying how different diets might affect MS risk and progression. The Mediterranean diet has been linked to a lower risk of developing MS and less severe symptoms compared to other diets. Ketogenic diets, which severely limit carbohydrates to promote ketone production, have shown promising results in animal studies and small human trials by slowing disease progression and improving symptoms in MS patients. This study compares the effects of two diets on quality of life in people with MS: a modified Atkins ketogenic diet that limits carbohydrates to 20 grams per day, and a Mediterranean diet based on traditional food guidelines. A control group will continue their usual diet and lifestyle. The study is designed as a three-arm, randomized pilot trial to evaluate these dietary patterns over six months. Participants will follow their assigned diets while researchers monitor health outcomes. Participants will be assessed at the start and after six months using the physical health subscale of the Multiple Sclerosis Quality of Life-54 questionnaire. Monthly phone interviews will check diet adherence, supplement use, physical activity, and nutrition habits. Other measures include neurological, nutritional, motor, and clinical outcomes to evaluate safety, feasibility, and overall effects of the diets during the study period.

Multiple Sclerosis and the Effects of Ketogenic Diet Therapy