Actively Recruiting
Multisite Implementation of COMPRENDO
Led by University of California, San Diego · Updated on 2026-02-20
450
Participants Needed
4
Research Sites
285 weeks
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
D
Dana-Farber Cancer Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring multilevel implementation factors that can inform real-world setting implementation. This study will test the impact of COMPRENDO, a peer-navigation intervention, vs. usual care on accrual to childhood cancer therapeutic clinical trials and parental informed consent outcomes. COMPRENDO will be delivered by trained peer navigators in 4 visits. A mixed methods (surveys, individual interviews) implementation evaluation will examine implementation factors that can inform the use of peer navigation in clinical practice, integrating data from clinicians, navigators, administrators, and parents pre and post the RCT.
CONDITIONS
Official Title
Multisite Implementation of COMPRENDO
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be a Hispanic parent or primary legal guardian
- Have a child aged 0 to 17 years with a new diagnosis of cancer or cancer-like disease (histiocytic disorders or myelodysplastic syndromes)
- Have a child eligible for a therapeutic cancer clinical trial
- Will participate in an informed consent discussion for the therapeutic clinical trial
- Understand written and spoken English or Spanish
- Have signed the consent form for the COMPRENDO study
You will not qualify if you...
- Have a second malignancy or relapse
- Child diagnosed at an outside institution
- Potential transfer of care to another institution within the next 4 months
- Previously participated in a clinical trial
- Do not understand written and spoken English or Spanish
- Not Hispanic
AI-Screening
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Trial Site Locations
Total: 4 locations
1
Children's of Alabama/University of Alabama at Birmingham
Birmingham, Alabama, United States, 35243
Actively Recruiting
2
Rady Children's Hospital San Diego/University of California San Diego Moores Cancer Center
San Diego, California, United States, 92123
Actively Recruiting
3
University of California San Francisco Benioff Children's Hospitals
San Francisco, California, United States, 94609
Actively Recruiting
4
Dana Farber Cancer Institute/Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
M
M.Paula Aristizabal, MD, MAS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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