Actively Recruiting
Multitarget Strategy for Primary Podocytopathies
Led by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Updated on 2026-03-27
150
Participants Needed
2
Research Sites
384 weeks
Total Duration
On this page
Sponsors
F
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Lead Sponsor
F
Fondazione Regionale per la Ricerca Biomedica
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to verify whether a cell culture system can be used to evaluate the presence of a factor capable of causing proteinuria in the serum of patients with primary podocytopathies. This system will also be used to evaluate the in vitro efficacy of a combined therapy for the treatment of this disorder. Researchers will compare samples from patients with primary podocytopathies with those obtained from healthy subjects and patients with other renal disorders. Participants will be asked to visit the clinic at regular intervals for up to 36 months, and to provide blood and urine samples (and a sample of the discarded plasmapheresis effluent in case the procedure is performed).
CONDITIONS
Official Title
Multitarget Strategy for Primary Podocytopathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent for study participation
- Diagnosis of primary podocytopathies (FSGS or MCD) with clinical or histological evidence of post-transplant recurrence
- Diagnosis of primary podocytopathies (FSGS or MCD) without evidence of post-transplant recurrence
- Active clinical phase of primary podocytopathies in native kidneys
- Podocytopathies with clinical features compatible with a secondary form due to another condition
- Glomerulonephritis other than primary podocytopathies (e.g., IgA nephropathy, systemic lupus erythematosus, membranous nephropathy)
- No history of renal diseases
You will not qualify if you...
- Primary podocytopathies or other glomerulonephritides in clinical remission or with end-stage renal disease (eGFR < 15 ml/min) and/or on renal replacement therapy
- Unable to understand and consent to study procedures
- Any clinical condition that could compromise patient safety during participation according to investigator judgment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy, 20122
Actively Recruiting
2
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Actively Recruiting
Research Team
M
Manuel A Podesta', MD, PhD
CONTACT
G
Giuseppe Castellano, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
0
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