Actively Recruiting
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma
Led by Abramson Cancer Center at Penn Medicine · Updated on 2025-11-28
15
Participants Needed
2
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
* To perform metabolic phenotyping of treatment naïve and recurrent GBM by multitracer \[18F\]Fluciclovine and 18F-FDG PET. * To compare uptake measures of 18F-Fluciclovine and 18F-FDG and MRI quantification of glutamate and lactate levels to tumor tissue laboratory assays (RNA seq and proteomics) of glutamine/glutamate, glucose, and lactate metabolism. * To perform metabolic phenotyping of treatment naïve and recurrent GBM by advanced MRI methods at 7 Tesla
CONDITIONS
Official Title
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants 18 years of age or older
- Diagnosis of a new intra-axial brain mass consistent with glioblastoma as confirmed by a neuroradiologist
- OR new or increased contrast-enhancing lesion(s) in patients with prior histologic or molecular diagnosis of glioblastoma after treatment
- Recommended for surgical tumor removal
- Life expectancy greater than 3 months as judged by a physician
- Karnofsky performance status of 60 or higher
- Willing and able to provide informed consent according to institutional and federal guidelines
You will not qualify if you...
- Unable to tolerate imaging procedures as determined by physician
- Pregnant or breastfeeding females at screening (pregnancy test required for women of childbearing potential)
- Any medical condition or illness that could compromise safety or participation as judged by a physician
- Contraindications to MRI
- Individuals unable to understand or provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
2
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
L
Leeanne Lezotte
CONTACT
J
Jeremy T Westerman, B.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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