Actively Recruiting
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Led by Imperial College London · Updated on 2025-06-06
60
Participants Needed
9
Research Sites
146 weeks
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
R
Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
Collaborating Sponsor
AI-Summary
What this Trial Is About
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 60 patients with multi-vessel coronary artery disease.
CONDITIONS
Official Title
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Eligibility for PCI due to angina
- Anatomical evidence of significant multi-vessel coronary stenosis defined by either:
- 50% stenosis in two or more coronary arteries of 2.5mm visual diameter stenosis, on invasive coronary angiography (ICA)
- Severe stenosis in 2 coronary arteries of 2.5mm visual diameter stenosis, on CTCA
- Physiological evidence of ischaemia with a positive test corresponding to the coronary arteries to be stented, on at least one of the following: dobutamine stress echocardiogram, cardiac MRI, myocardial perfusion study, invasive metrics of coronary physiology
You will not qualify if you...
- Recent acute coronary syndrome
- Previous coronary artery by-pass graft surgery (CABG)
- Significant left main stem disease
- Chronic total occlusion in the target artery(s)
- Moderate to severe valvular disease
- Moderate to severe left ventricular impairment
- Contraindication to PCI or a drug-eluting stents
- Contraindication to antiplatelet therapy
- Contraindication to adenosine
- Pregnant
- Inability to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Essex Cardiothoracic Centre
Basildon, United Kingdom
Actively Recruiting
2
Royal Bournemouth Hospital
Bournemouth, United Kingdom
Actively Recruiting
3
Royal Sussex County Hospital
Brighton, United Kingdom, BN2 5BE
Actively Recruiting
4
Imperial College NHS Trust
London, United Kingdom
Actively Recruiting
5
Royal Free London NHS Foundation Trust
London, United Kingdom
Actively Recruiting
6
St Georges University Hospital
London, United Kingdom
Actively Recruiting
7
Nottingham City Hospital
Nottingham, United Kingdom, NG5 1PB
Actively Recruiting
8
Portsmouth Hospitals University NHS Trust
Portsmouth, United Kingdom
Not Yet Recruiting
9
University Hospital Southampton
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
S
Shayna Chotai, MBBS MRCP
CONTACT
R
Rasha Al-Lamee, PhD MRCP
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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