Actively Recruiting
Muscle Blood Flow Regulation in HFpEF
Led by VA Office of Research and Development · Updated on 2026-04-21
35
Participants Needed
1
Research Sites
295 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression. This research proposal aims to elucidate mechanisms responsible for inadequate skeletal muscle blood flow and exercise intolerance in patients with HFpEF compared with healthy controls as well as following 8 weeks of exercise training in patients with HFpEF only.
CONDITIONS
Official Title
Muscle Blood Flow Regulation in HFpEF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and able to give written informed consent
- New York Heart Association (NYHA) functional class II or III
- Left Ventricular Ejection Fraction (LVEF) > 50%
- Plasma Brain Natriuretic Peptide (BNP) >200 pg/mL or NT-proBNP 400 pg/mL at enrollment
You will not qualify if you...
- Prior ejection fraction less than 50%
- NYHA Class IV or heart failure that cannot be stabilized on optimized pharmacotherapy
- Acute coronary syndrome, infiltrative cardiomyopathy, or myocarditis
- HFpEF caused by significant uncorrected primary valvular disease (except mitral regurgitation due to left ventricular dysfunction)
- Orthopedic problems preventing knee-extensor exercise
- Women currently using hormone replacement therapy
- Women who are pregnant or may become pregnant
- Current smokers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States, 84148-0001
Actively Recruiting
Research Team
K
Kanokwan Bunsawat, PhD
CONTACT
D
David W Wray, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here