Measuring Muscle Health and Disease Changes Using Electrical Impedance Myography Compared to MRI in Adults with Myopathy

What this Trial Is About

Researchers are investigating a device called the mScan, which uses Electrical Impedance Myography EIM to measure muscle health in people with and without muscle diseases. The study aims to compare the mScans measurements with those from magnetic resonance imaging MRI, which is commonly used to track muscle conditions but has limitations like high cost and inconvenience. The goal is to develop a quicker, easier, and less expensive way to assess muscle health that could help monitor treatment effects in muscle disorders. The study involves using the mScan device, which applies a small, painless electrical current to muscles and records the muscles response. This technology is being studied as a potential alternative to MRI because it is faster, more convenient, and does not require complex image analysis. Participants include healthy individuals and those with muscle diseases called myopathies. The study compares muscle measurements from the mScan with those from MRI over two years. Participants will undergo assessments using both the mScan device and MRI scans to collect data on muscle condition, including muscle size, fat content, swelling, and fiber organization. Researchers will apply machine learning to connect the mScan data with MRI findings to create predictive models of muscle pathology. The study may also involve DXA scans and excludes those with certain conditions that interfere with these tests. The total study duration is two years, focusing on developing algorithms to improve muscle disease assessment.

Muscle Health Measurements Using Electrical Impedance Myography