Actively Recruiting
The MUSE Study for Menopausal Arthralgia
Led by National University Hospital, Singapore · Updated on 2024-07-31
100
Participants Needed
1
Research Sites
191 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators plan to conduct a pilot 4-arm, randomized study comprising the following interventions: muscle strengthening exercises (MSE) alone, estrogen therapy (ET) alone, and a combination of MSE and ET, compared to usual care in women with menopausal arthralgia. The aim of this pilot study is to assess the feasibility, patient acceptability, and patient perspectives and logistics of delivering interventions, and practicability of outcome assessment tools in this 4-arm study over a 12-week period.
CONDITIONS
Official Title
The MUSE Study for Menopausal Arthralgia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with muscle stiffness and joint discomfort in multiple sites such as hands, knees, back, hips, or shoulders
- Arthralgia symptoms started or worsened during perimenopause or early postmenopause (within 5 years of menopause)
- Women aged 30 to 59 years or within 5 years of menopause at enrollment
- Arthralgia lasting at least 3 months
- Community-dwelling and able to walk independently
You will not qualify if you...
- History of blood clots, strokes, heart disease, dementia, psychiatric disorders, liver or kidney disease, severe high cholesterol, gout, thyroid disease, lupus, rheumatoid arthritis, or other chronic inflammatory conditions
- Pregnancy
- Not following breast cancer screening guidelines
- High risk of breast cancer
- Joint surgery within last 6 months
- Severe obesity (BMI over 35)
- Migraine with aura
- Poorly controlled diabetes
- Use of female hormone therapy in past 12 weeks
- High risk of venous thromboembolism
- Current gallbladder inflammation, fibroids, or unexplained abnormal uterine bleeding
- Current smoker
- History of certain cancers (endometrial, ovarian, peritoneal, cervical, breast, endocrine-dependent)
- Receiving cancer treatment
- Fragility bone fractures within last 2 years
- Any cognitive, musculoskeletal, neurological, or heart/lung condition affecting study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National University Hospital
Singapore, Singapore
Actively Recruiting
Research Team
E
Eu-Leong Yong, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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