Actively Recruiting
Myasthenia Gravis Registry in China
Led by Huashan Hospital · Updated on 2024-02-05
1500
Participants Needed
16
Research Sites
573 weeks
Total Duration
On this page
Sponsors
H
Huashan Hospital
Lead Sponsor
C
China Alliance for Rare Diseases
Collaborating Sponsor
AI-Summary
What this Trial Is About
Myasthenia gravis (MG) is an autoimmune disease caused by dysfunction at the neuromuscular junction, characterized by partial or generalized skeletal muscle weakness and fatigability. The estimated annual incidence rate of MG in China is 0.68/100,000, with a high rate of relapse and poor treatment compliance. This study is a prospective, observational, multi-center patient registry across China. To support standardized management and follow-up of MG patients in China, a Cloud-based MG Patient Management Platform (CN MG Base) was established in September 2023 with the support of the Chinese Rare Diseases Alliance. The platform aims to collect longitudinal clinical data including demographic information, age of onset, medical history, comorbidities, medication usage, treatment responses, and others. It is intended to collect newly registered MG cases each year and follow up with these patients at one-year intervals for ten years
CONDITIONS
Official Title
Myasthenia Gravis Registry in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fluctuating weakness in skeletal muscles such as extraocular, bulbar, or limb muscles, with weakness worsening with activity and improving with rest
- Ability of patients or guardians to understand and sign informed consent
- At least one of the following: positive Tensilon test; decrease in compound muscle action potential by over 10% with low-frequency repetitive nerve stimulation or increased jitter on single-fiber electromyography; or positive serum antibodies for AChR, MuSK, or LRP4
You will not qualify if you...
- Patients with mental illness who cannot cooperate with the study
- Patients with multiple organ dysfunction or in extremely critical condition unable to complete medical history or evaluation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 16 locations
1
Beijing Hospital
Beijing, Beijing Municipality, China, 100051
Actively Recruiting
2
Xuanwu hospital, Capital medical university
Beijing, Beijing Municipality, China, 100053
Actively Recruiting
3
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
4
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 401147
Actively Recruiting
5
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060
Actively Recruiting
6
The Third Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060
Actively Recruiting
7
First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
8
Xiangya hospital, Central south university
Changsha, Hunan, China, 410001
Actively Recruiting
9
The First Hospital, Soochow University
Suzhou, Jiangsu, China, 215005
Actively Recruiting
10
Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China, 221004
Actively Recruiting
11
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330209
Actively Recruiting
12
The First Hospital, Jilin University
Changchun, Jilin, China, 130021
Actively Recruiting
13
Huashan Hospital, Fudan University
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
14
Tangdu Hospital, The Air Force Medical University
Xi’an, Shanxi, China, 710000
Actively Recruiting
15
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
16
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China, 300052
Actively Recruiting
Research Team
S
Sushan Luo, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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