Actively Recruiting
Myo-inositol During Pregnancy to Prevent Gestational Diabetes
Led by Tufts Medical Center · Updated on 2025-04-29
40
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Myoinositol is an insulin-like compound that is present in both plant and animal cells. Humans synthesize it naturally, but it is also obtained in our diet. It works through an intracellular signaling pathway to increase insulin sensitivity. Myoinositol has been used as an over-the-counter (OTC) supplement in the management of polycystic ovarian syndrome due to this effect. Myoinositol has also been shown to improve glycemic profiles in pregnant euglycemic women and well as improve insulin sensitivity in pregnant patients with gestational diabetes mellitus (GDM). This is a double blind RCT offering myo-inositol or placebo to those who are eligible and enrolled.
CONDITIONS
Official Title
Myo-inositol During Pregnancy to Prevent Gestational Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Singleton gestations
- Women aged > 18 years and < 45 years
- Recruited before 16 weeks gestation
- Obese (pre-pregnancy BMI 8 30)
- Receiving prenatal care at Tufts Medical Center
- Planning to give birth at Tufts Medical Center
- Can tolerate glucose tolerance test
- Willing and able to wear CGM
- Willing and able to sign informed consent
You will not qualify if you...
- Multiple gestation
- Preexisting diabetes
- Taking medications that impact body weight or metabolism (eg metformin)
- Inability to tolerate glucose tolerance test
- Adults unable to consent (cognitively impaired adults)
- Wards of the state
- Non-viable neonates
- Neonates of uncertain viability
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
Research Team
Z
Zeinab Kassem, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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