Actively Recruiting
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Led by Northwestern University · Updated on 2026-04-09
180
Participants Needed
6
Research Sites
107 weeks
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.
CONDITIONS
Official Title
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 30 years or older
- Left ventricular ejection fraction 50% or higher measured by echocardiography, CMR, or MUGA within one year with clinical stability
- Signs or symptoms of heart failure with NYHA functional class II-IV
- Elevated BNP or NT-proBNP levels based on specific thresholds or prior heart failure hospitalization with elevated natriuretic peptides
- Documented elevated pulmonary capillary wedge pressure at rest or during exercise, or elevated H2FPEF or HFA-PEFF scores
- For suspected HFpEF: age 30 years or older, left ventricular ejection fraction 50% or higher, signs or symptoms of heart failure with NYHA class II-IV, and not meeting BNP/NT-proBNP or hospitalization criteria
You will not qualify if you...
- Inadequate echocardiogram or fluoroscopic images
- Unfavorable neck anatomy for jugular venous cannulation
- Current therapy with direct oral anticoagulants without adequate cessation
- Current or recent warfarin therapy with INR 1.6 or higher at biopsy
- Platelet count below 50,000/ml
- Active bleeding or coagulation disorder
- Infection or fever
- Endocarditis
- Pregnancy
- Intracardiac thrombus
- Right ventricular aneurysm
- Significant valve stenosis of tricuspid, pulmonary, or aortic valves
- Mechanical valve prosthesis in tricuspid or pulmonary position
- Left bundle branch block
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
2
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
3
Mass General Brigham
Boston, Massachusetts, United States, 02114
Actively Recruiting
4
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
5
Wake Forest University
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
6
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
L
Laura Alagna
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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