Actively Recruiting
Myocardial Perfusion Quantification With Single Photon Emission Computed Tomography Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary Computed Tomography Angiography
Led by Semmelweis University · Updated on 2025-04-25
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the relationship between functional abnormalities detected by myocardial perfusion SPECT imaging (MPI SPECT) and anatomical findings seen on coronary computed tomography angiography (coronary CTA) in patients suspected of having coronary artery disease (CAD). The study focuses on patients with moderate cardiovascular risk and aims to improve the diagnostic value of MPI SPECT by measuring myocardial blood flow and myocardial flow reserve (MFR) using advanced imaging technology. The purpose is to enhance risk assessment and diagnostic accuracy for this patient group. Participants will undergo several imaging tests within 30 days, including dynamic and static MPI SPECT with pharmacological stress and rest phases, using a multi-pinhole collimator and a standard LEHR collimator. Additionally, cardiac CT scans, including calcium scoring and coronary CTA with a photon-counting detector, will be performed. These tests provide detailed functional and anatomical data that will be compared and analyzed to assess their association and predictive value for coronary artery disease. During the study, patients will have their myocardial blood flow, myocardial flow reserve, and perfusion defects evaluated through MPI SPECT, along with coronary artery calcium scores, plaque volume, and stenosis severity from coronary CTA. Researchers will collect clinical information such as age, sex, and cardiovascular risk factors to support statistical modeling. The primary outcome is the association between myocardial flow reserve and non-calcified plaque volume, with several secondary outcomes related to blood flow, plaque composition, and diagnostic accuracy. The study will conclude after patient enrollment and data analysis, lasting until 2026.
CONDITIONS
Brief Title
Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suspected coronary artery disease
- Referred to coronary CTA or SPECT MPI by the patient's physician
- Agrees to undergo the other imaging modality not initially indicated
- Suitable for providing informed consent
You will not qualify if you...
- Moderate or severe aortic valve stenosis
- Atrial fibrillation
- Pregnancy or breastfeeding
- History of coronary artery bypass graft implantation
- History of stent implantation
- Chronic renal failure (eGFR < 30 ml/m2)
- Active oncological treatment
- Congenital heart disease
- Left or right bundle branch block
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 30 days
Participants undergo dynamic and static myocardial perfusion SPECT (MPI SPECT) imaging under pharmacological stress and at rest, followed by coronary CT angiography within 30 days. These diagnostic tests assess myocardial blood flow and coronary artery plaque characteristics to evaluate coronary artery disease.
1 day for MPI SPECT imaging and 1 visit for coronary CT within 30 days
Trial Site Locations
Total: 1 location
1
Semmelweis University, Medical Imaging Centre
Budapest, Budapest, Hungary, 1083
Actively Recruiting
Research Team
P
Pál Maurovich-Horvat, Prof. Dr.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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