Actively Recruiting
Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA
Led by Semmelweis University · Updated on 2025-04-25
50
Participants Needed
1
Research Sites
129 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography (coronary CTA). Additionally, the investigators aim to enhance the diagnostic value of MPI SPECT by quantifying myocardial blood flow and utilizing myocardial flow reserve calculated from dynamic SPECT images. 50 patients with suspected coronary artery disease are anticipated to be enrolled. Pharmacological stress and rest-phase dynamic and static MPI SPECT following an additional coronary CTA scan are to be performed. The obtained multimodality imaging data (functional and anatomical parameters) are planned to be compared and subjected to statistical analysis. The results of this study are expected to improve risk assessment for patients with moderate cardiovascular risk and enhance the diagnostic performance of MPI SPECT.
CONDITIONS
Official Title
Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Suspected coronary artery disease
- Referred to coronary CTA or SPECT MPI by the patient's physician
- Agrees to undergo the other imaging test not initially indicated (coronary CTA or SPECT MPI)
- Able to provide informed consent
You will not qualify if you...
- Moderate or severe aortic valve stenosis
- Atrial fibrillation
- Pregnancy or breastfeeding
- History of coronary artery bypass graft implantation
- History of stent implantation
- Chronic renal failure with eGFR below 30 ml/m2
- Active cancer treatment
- Congenital heart disease
- Left or right bundle branch block
AI-Screening
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Trial Site Locations
Total: 1 location
1
Semmelweis University, Medical Imaging Centre
Budapest, Budapest, Hungary, 1083
Actively Recruiting
Research Team
P
Pál Maurovich-Horvat, Prof. Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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