Actively Recruiting
Comparing Multi-Pinhole SPECT Myocardial Blood Flow Quantification with Photon-Counting Coronary CT Angiography for Heart Disease Diagnosis
Led by Semmelweis University · Updated on 2025-04-25
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating the relationship between functional abnormalities detected by myocardial perfusion SPECT imaging MPI SPECT and anatomical findings seen on coronary computed tomography angiography coronary CTA in patients suspected of having coronary artery disease CAD. The study focuses on patients with moderate cardiovascular risk and aims to improve the diagnostic value of MPI SPECT by measuring myocardial blood flow and myocardial flow reserve MFR using advanced imaging technology. The purpose is to enhance risk assessment and diagnostic accuracy for this patient group. Participants will undergo several imaging tests within 30 days, including dynamic and static MPI SPECT with pharmacological stress and rest phases, using a multi-pinhole collimator and a standard LEHR collimator. Additionally, cardiac CT scans, including calcium scoring and coronary CTA with a photon-counting detector, will be performed. These tests provide detailed functional and anatomical data that will be compared and analyzed to assess their association and predictive value for coronary artery disease. During the study, patients will have their myocardial blood flow, myocardial flow reserve, and perfusion defects evaluated through MPI SPECT, along with coronary artery calcium scores, plaque volume, and stenosis severity from coronary CTA. Researchers will collect clinical information such as age, sex, and cardiovascular risk factors to support statistical modeling. The primary outcome is the association between myocardial flow reserve and non-calcified plaque volume, with several secondary outcomes related to blood flow, plaque composition, and diagnostic accuracy. The study will conclude after patient enrollment and data analysis, lasting until 2026.
CONDITIONS
Brief Title
Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA
Research Team
P
Pál Maurovich-Horvat, Prof. Dr.
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