Actively Recruiting
N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-02-10
45
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out whether N10 chemotherapy is a safe and effective treatment for children with high-risk neuroblastoma.
CONDITIONS
Official Title
N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of neuroblastoma confirmed by histopathology, bone marrow metastases with high urine catecholamine levels, or positive MIBG scan
- High-risk neuroblastoma defined as MYCN-amplified stage L2/M/MS at any age or stage M in patients older than 18 months
- No more than one prior cycle of high-risk neuroblastoma chemotherapy
- Age younger than 19 years
- Signed informed consent acknowledging the investigational nature of the treatment
You will not qualify if you...
- Severe dysfunction of major organs (renal, cardiac, hepatic, neurologic, pulmonary, hematologic, or gastrointestinal) at grade 3 or higher
- Organ dysfunction caused directly by tumor effects, metastatic disease, or related paraneoplastic syndromes is not exclusionary
- Inability to follow study protocol requirements
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
Research Team
B
Brian Kushner, MD
CONTACT
F
Fiorella Iglasias Cardenas, MD, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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