Actively Recruiting
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
Led by Kaiser Permanente · Updated on 2025-03-12
304
Participants Needed
1
Research Sites
198 weeks
Total Duration
On this page
Sponsors
K
Kaiser Permanente
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery
CONDITIONS
Official Title
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided informed consent before any study-related activities
- Men or women older than 18 years scheduled for non-emergent cardiac surgery requiring cardiopulmonary bypass
- Scheduled for procedures including CABG, or aortic, mitral, tricuspid, or pulmonic valve replacement or repair, or combined CABG with valve procedures
- Presence of one or more risk factors for adverse cardiovascular outcomes such as valve surgery, eGFR less than 45 ml/min/1.73m2, left ventricular ejection fraction 35% or less within six months before surgery, history of heart failure, insulin-requiring diabetes, non-insulin-requiring diabetes with significant proteinuria, preoperative anemia (hemoglobin less than 11 g/dl), prior CABG, or age 65 years or older
You will not qualify if you...
- Acute kidney injury within seven days before surgery as defined by KDIGO stage 1 or higher
- Kidney transplant recipient
- Off-pump cardiac surgery
- End-stage renal disease
- Emergent cardiac surgery
- Pregnancy
- Participation in competing research studies that may affect outcomes
- Patients held in an institution by legal or official order
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Kaiser Permanente San Francisco Medical Center
San Francisco, California, United States, 94115
Actively Recruiting
Research Team
A
Ali Poyan Mehr, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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