Actively Recruiting
Naltrexone Neuroimaging in Teens With Eating Disorders
Led by Children's Mercy Hospital Kansas City · Updated on 2025-11-25
60
Participants Needed
1
Research Sites
245 weeks
Total Duration
On this page
Sponsors
C
Children's Mercy Hospital Kansas City
Lead Sponsor
U
University of Kansas Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders. The hypothesis is that fMRI will be able to detect acute reward pathway modulation by naltrexone (an opioid antagonist) in pre-defined regions of interest (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex).
CONDITIONS
Official Title
Naltrexone Neuroimaging in Teens With Eating Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adolescents and young adults aged 13-21 years
- Diagnosis of an eating disorder with binge eating and/or purging using DSM-V criteria
- Stable medication regimen with no dose or drug changes in the past 4 weeks
- Willingness and ability of participant and parent/legal guardian (if under 18) to provide informed permission/assent/consent
You will not qualify if you...
- Pregnant
- Prior hypersensitivity reaction to naltrexone, including anaphylaxis
- Presence of non-removable metal in the body incompatible with MRI
- Current use of naltrexone
- Self-reported opioid use in the past 7 days
- Language barrier preventing communication or completion of study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Mercy Research Institute
Kansas City, Missouri, United States, 64108
Actively Recruiting
Research Team
M
Mariah L Brewe, BA
CONTACT
S
Stephani Stancil, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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