Naltrexone Treatment for Alcoholism Predicting Outcome

Led by Johns Hopkins University · Updated on 2010-05-14

192

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This study will evaluate the effectiveness of the medication naltrexone (Revia) for treating alcoholism. Individuals will be inpatients for a 2 week period and provide assessments of their alcohol withdrawal symptoms, craving, and mood. Following hospital discharge, individuals will be assigned randomly to receive naltrexone daily, naltrexone twice a day or a placebo. This part of the study will last 12 weeks, with regular measurements of drinking level, craving and mood. Assessments will be conducted 6 and 12 months after the beginning of the study.

CONDITIONS

Brief Title

Naltrexone Treatment for Alcoholism

Who Can Participate

Age: 30Years - 55Years

All Genders

Eligibility Criteria

Inclusion Criteria:

Meets criteria for alcohol dependence.
Committed to alcohol abstinence as a treatment goal.
Individuals will be required to identify two family members or close friends who are knowledgeable about their location, drinking behavior, and psychosocial status.

Exclusion Criteria:

Meets criteria for any other psychoactive substance use disorder (excluding nicotine and caffeine).
Meets criteria for a major psychiatric disorder and are in need of or currently undergoing pharmacotherapy.
Females who are pregnant, lactating, or not using a reliable method of contraception.
Currently experiencing a serious medical condition that would place them at risk or interfere with study participation.
Experiencing acute hepatitis or liver failure or whose liver function test is more than 3 times normal.
Have a history of severe allergies, multiple adverse drug reactions or known allergy to naltrexone.
Vocabulary below the 5th grade reading level.
Abnormal MRI scan.
HIV infection due to the neurological sequelae.
Significant central nervous system diseases.
Seizure disorder or history of closed head trauma.
Neuroendocrine disorders.
Treatment with opiates within the last six months.

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Naltrexone Treatment for Alcoholism Predicting Outcome

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria