Actively Recruiting
Nasal Obstruction With Oxymetazoline and Corticosteroids
Led by Washington University School of Medicine · Updated on 2025-09-11
80
Participants Needed
1
Research Sites
115 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to examine the efficacy and safety of commination oxymetazoline/intranasal steroids for long-term management of chronic nasal obstruction that is recalcitrant to the current standard of care. The investigators hypothesize that combination treatment with oxymetazoline and intranasal corticosteroid spray will provide a larger reduction in nasal obstruction than intranasal corticosteroid alone for patients suffering from chronic nasal obstruction, and there will not be occurrences of rhinitis medicamentosa.
CONDITIONS
Official Title
Nasal Obstruction With Oxymetazoline and Corticosteroids
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older
- History of nasal obstruction
- Failed prior daily use of topical steroids for at least 1 month
- Able to read, write, and understand English
- Do not want surgery or are poor surgical candidates due to other medical conditions
- Prior use of oxymetazoline or other nasal decongestants allowed if stopped at least 4 weeks before enrollment
- Willing to stop using other nasal sprays except saline and to avoid oral decongestants during the study
You will not qualify if you...
- History of sinonasal mass or tumor
- History of nasal polyps
- Known chronic sinusitis
- Allergy to oxymetazoline
- Medical contraindication to oxymetazoline use such as pulmonary hypertension
AI-Screening
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Trial Site Locations
Total: 1 location
1
Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
N
Nyssa Farrell, MD
CONTACT
S
Sara Kukuljan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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