Actively Recruiting
Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis
Led by University of Alabama at Birmingham · Updated on 2026-03-17
20
Participants Needed
1
Research Sites
673 weeks
Total Duration
On this page
Sponsors
U
University of Alabama at Birmingham
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms underlying Chronic Rhinosinusitis (CRS), creating a localized environment that impairs mucociliary clearance (MCC).
CONDITIONS
Official Title
Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of chronic rhinosinusitis (CRS) based on Sinus and Allergy Health Partnership criteria with symptoms lasting 12 weeks or more
- Presence of signs of nasal inflammation such as discolored nasal drainage, nasal polyps, middle meatus or ethmoid bulla swelling, or confirmed mucosal changes on CT scan
- Age 19 years or older
- Weight at least 50 kilograms
- Ability to perform Nasal Potential Difference (NPD) testing
- Negative pregnancy test for females of childbearing potential
- Provide written informed consent
You will not qualify if you...
- Acute illness within 2 weeks before starting study procedures
- Major asthma attack within 2 months prior to study
- Change in intranasal medications within 14 days before study
- Positive test for hepatitis B, hepatitis C, or HIV
- Hemoglobin less than 10 gm/dL or serum albumin less than 2.5 g/dL
- Abnormal liver function tests above twice the normal range
- Abnormal kidney function with serum creatinine above 1.5 times normal
- Pregnancy or breastfeeding
- History of solid organ or blood cell transplantation
- History of autoimmune or granulomatous disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35244
Actively Recruiting
Research Team
N
Norma Miller, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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