Actively Recruiting
Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis
Led by Daniel Merenstein · Updated on 2026-03-03
3720
Participants Needed
7
Research Sites
262 weeks
Total Duration
On this page
Sponsors
D
Daniel Merenstein
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Sinus infections (also called acute rhinosinusitis or ARS) affect about 15% of adults each year, and are one of the top reasons people receive antibiotics in outpatient settings. Since most sinus infections are caused by viruses, many patients who take antibiotics for this condition do not actually benefit. Even though this has decreased over recent years, 70% of people are still prescribed them after a visit for ARS. Our goal is to better understand which patients truly benefit from antibiotics and which other treatment options can help people with sinus infections.
CONDITIONS
Official Title
Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Having sinus infection symptoms lasting 1 to 21 days without signs of improvement
- Or experiencing worsening symptoms after initial improvement, such as new fever, headache, or increased nasal discharge following a viral upper respiratory infection
You will not qualify if you...
- Allergy or intolerance to penicillin
- Use of systemic antibiotics in the past 4 weeks
- Prior sinus surgery (except cosmetic procedures like rhinoplasty or septal deviation)
- Complications of sinusitis such as facial swelling or signs affecting eyes or brain
- Need for intravenous antibiotics or hospital admission as determined by healthcare clinician
- Pregnancy or breastfeeding
- Having conditions or medications that impair the immune system as determined by healthcare clinician
- Hospitalization within the past 5 days
- Unable or unwilling to provide informed consent or follow study requirements
- Current fever above 39°C (102°F)
- Regular use of intranasal corticosteroids in the past two weeks without willingness to stop during study
- Previous participation in this study or its feasibility phase
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
University of California, Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
2
Georgetown University Medical Center
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
3
MedStar Health Research Institute
Hyattsville, Maryland, United States, 20782
Not Yet Recruiting
4
Penn State College of Medicine
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
5
Virginia Commonwealth University
Richmond, Virginia, United States, 23219
Actively Recruiting
6
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
7
University of Wisconsin-Madison
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
L
Lead Project Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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