Actively Recruiting
NASH AMPK Exercise Dosing (AMPED) Trial
Led by Milton S. Hershey Medical Center · Updated on 2025-10-14
45
Participants Needed
1
Research Sites
202 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is no known cure or regulatory agency approved drug therapy for nonalcoholic fatty liver disease (NAFLD), the leading cause of liver disease worldwide, and its progressive type, NASH. This places increased importance on using exercise to treat NAFLD. While physical activity is recommended for all with NAFLD, how to best prescribe exercise as a specific treatment remains unknown, including what dose of exercise is most effective.
CONDITIONS
Official Title
NASH AMPK Exercise Dosing (AMPED) Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-69 years
- Sedentary, defined as less than 90 minutes of exercise per week by the Get Active Questionnaire (GAQ)
- Body mass index (BMI) over 25 kg/m2
- Liver biopsy within six months prior to enrollment showing NASH defined by the NASH Clinical Research Network histology scoring system with NAS greater than 4 and MRI-PDFF greater than 5%
- Liver fibrosis stage 1 to 3
You will not qualify if you...
- Active cardiac symptoms
- Body mass index (BMI) over 45 kg/m2
- Active cancer
- Inability to walk more than 2 blocks
- Institutionalized or prisoner
- Other liver disease
- Pregnancy
- Secondary hepatic steatosis
- Severe comorbidities
- Significant alcohol use identified by AUDIT-C questionnaire
- Substance abuse or active smoking
- Uncontrolled diabetes with changes in drug dosing over the previous three months or A1c greater than 9%
- GAQ response indicates exercise may be unsafe
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
Research Team
B
Breianna L Hummer, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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