Actively Recruiting
Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis: A Randomized Controlled Pilot Study
Led by Post Graduate Institute of Medical Education and Research, Chandigarh · Updated on 2026-02-09
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether nasojejunal feeding is better than oral feeding in patients undergoing endoscopic drainage of walled off pancreatic necrosis after acute pancreatitis. This randomized control trial aims to assess differences in infection rates, feed tolerance, weight gain, and the need for re-intervention between the two feeding methods. The study is conducted with adult patients aged 18 to 75 years who have symptomatic walled off necrosis requiring drainage. Participants will be randomly assigned to receive either nasojejunal feeding or start oral feeding following an endoscopic ultrasonography guided cystogastrostomy procedure. The nasojejunal tube will be placed immediately after the drainage procedure for those in the experimental group, while the comparator group will begin oral feeding. This pilot study will monitor the effects of each feeding method over a period of 14 days. During the study, researchers will closely monitor nutritional failure as the primary outcome within 14 days. Secondary outcomes include the incidence of infections, new onset organ failure, re-intervention rates, weight changes, and inflammatory marker levels during the same timeframe. Participants will be followed for the full 14 days after their procedure to assess these measures and to ensure safety and proper monitoring throughout the study period.
CONDITIONS
Brief Title
Nasojejunal Feeding Versus Oral Feeding Following Endoscopic Drainage of Walled Off Pancreatic Necrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 75 years
- Diagnosis of acute pancreatitis with symptomatic walled off necrosis
- Requirement for endoscopic ultrasound-guided transluminal drainage
- Provision of written informed consent
You will not qualify if you...
- Collections not suitable for endoscopic ultrasound-guided drainage (distance from gastrointestinal lumen >1 cm)
- Known malignancy or immunocompromised state
- Previous upper gastrointestinal surgery affecting absorption
- Active gastrointestinal bleeding
- Gastrointestinal obstruction, ileus, or persistent vomiting
- Moribund patients unfit for endoscopic procedure (Glasgow coma scale <8 or on ventilatory support)
- Irreversible coagulopathy (platelets <50,000/mm3 and/or INR >1.5)
- Pregnant or lactating females
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 14 days
Participants undergo endoscopic ultrasonography guided cystogastrostomy and receive either nasojejunal feeding or start an oral diet after randomization.
1 procedure visit and daily feeding during treatment period
Trial Site Locations
Total: 1 location
1
Post Graduate Institute of Medical Education and Research (PGIMER)
Chandigarh, India, 160012
Actively Recruiting
Research Team
S
Saurabh Kumar Singh
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here