Actively Recruiting
National Cohort on Congenital Defects of the Eye
Led by Institut National de la Santé Et de la Recherche Médicale, France · Updated on 2026-02-12
800
Participants Needed
1
Research Sites
1042 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Congenital malformations of the eye comprise various developmental defects including microphthalmia, anophthalmia, aniridia, and anterior segment anomalies (such as Peters and Axenfeld-Rieger anomalies). These malformations are frequently associated with extra-ocular features and intellectual disability. However, little is known about visual outcome, frequency and consequences of extra-ocular features in patients. The originality of the project will be to include a spectrum of malformation thought to be a phenotypic continuum (anophthalmia, microphthalmia, aniridia, anterior segment dysgnesis). In addition, we aim to conduct a 10 year follow-up of these children, thus allowing determining ocular and neurological outcomes as any other medical event. We should also be able to determine phenotypic factors that would be associated with good or poor visual and neurologic outcomes
CONDITIONS
Official Title
National Cohort on Congenital Defects of the Eye
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newborns and children from birth to 7 years old with anophthalmia, microphthalmia, aniridia, or anterior segment dysgenesis whose parents have given informed consent
- Patients affiliated with the French National Health Insurance or foreign patients agreeing to pay medical fees through French centers
- Adults with anophthalmia, microphthalmia, aniridia, or anterior segment dysgenesis
- Adults under guardianship with informed consent from guardians
- Adults able to provide informed consent
- Adult parents of affected children willing to participate in genetic inheritance studies
- Pregnant women can be included
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
RaDiCo-ACOEIL
Paris, Île-de-France Region, France, 75012
Actively Recruiting
Research Team
N
Nicolas NC CHASSAING, Dr
CONTACT
P
Patrick CALVAS, Pr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here