Actively Recruiting
A National Screening Program for Islet Autoantibodies Among First-degree Relatives of T1D Patients
Led by Rabin Medical Center · Updated on 2025-05-20
20000
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A national Screening program for the presence of Islet Autoantibodies (IA) in relatives of people with type 1 diabetes (PWT1D) aiming at identifying people with pre-clinical (stage 1 \& 2) T1D and DKA prevention on the clinical presentation of T1D. All participants will be screened at study entry for the presence of 4 islet autoantibodies: glutamic acid decarboxylase antibody (GADA), insulinoma-associated-2 antibody (IA-2A), insulin antibodies (IAA) and Zinc transporter-8 antibodies (ZnT8A). The ADAP assay will be used to detect IA. A confirmation blood sample for positive participants with two or more IA will be taken. The confirmation analysis will be done by the ADAP assay, conventional ELISA, and RIA. Participants identified as part of the study with pre-symptomatic type 1 diabetes (T1D) (stages 1 and 2) will be referred to complete an educational program emphasizing DKA prevention as part of routine medical care .During the study, cases of stage 2 and stage 3 diabetes and DKA events in participants who are positive for IA will be documented.
CONDITIONS
Official Title
A National Screening Program for Islet Autoantibodies Among First-degree Relatives of T1D Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 2 to 45 years
- First-degree relatives of Type 1 Diabetes probands
- Signing an informed consent
You will not qualify if you...
- Known diabetes of any kind (type 1, type 2, MODY)
- Previous treatment with insulin or oral diabetes medications
- Current use of systemic immunosuppressive agents (topical and inhaled agents allowed)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Schneider Children Medical Center of Israel
Petah Tikva, Israel
Actively Recruiting
Research Team
M
Moshe Phillip, Prof.
CONTACT
A
Alona Hamou, Msc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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