Actively Recruiting
Natriuresis-guided Depletion After Cardiac Surgery
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-01-21
102
Participants Needed
1
Research Sites
118 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical. Recent data suggest that natriuresis-guided furosemide titration using point-of-care urinary sodium sensors (LAQUAtwin NA-11, Horiba) may improve the efficiency and safety of fluid removal, but no randomized trial has yet evaluated this approach in postoperative cardiac surgery patients Our goal is to assess the clinical impact, safety, and feasibility of a natriuresis-guided furosemide protocol after cardiac surgery requiring cardiopulmonary bypass.
CONDITIONS
Official Title
Natriuresis-guided Depletion After Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (age > 18 years)
- Scheduled for cardiac surgery including mitral valve repair or replacement, aortic valve replacement, coronary artery bypass grafting (CABG), ascending aortic repair, or combined procedures
- Undergoing surgery with cardiopulmonary bypass (CPB)
- Eligible to receive intravenous furosemide for fluid overload within 48 hours following surgery as prescribed by the referring physician
- Written and oral informed consent obtained
- Covered by the French national health insurance (Sécurité Sociale)
You will not qualify if you...
- Aortic arch repair requiring deep hypothermic circulatory arrest
- Active endocarditis
- Hemodynamic instability requiring vasopressor or inotropic support (norepinephrine, dobutamine, epinephrine, or vasopressin)
- Failure to wean from CPB requiring mechanical circulatory support
- Chronic kidney disease with an estimated glomerular filtration rate (eGFR) < 60 mL/min
- Chronic use of loop diuretics
- Known allergy to furosemide
- Active postoperative bleeding and/or reoperation for bleeding
- Participation in another interventional study that may affect the primary outcome measure
- Patient deprived of liberty by administrative or judicial decision, or placed under legal protection (guardianship or curatorship)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU Amiens Picardie
Amiens, France, 80000
Actively Recruiting
Research Team
C
Christophe Beyls, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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