Efficacy of a Natural Bioactive Gel as an Adjunct to Standard Therapy in the Treatment of Peri-Implantitis: A Randomized Controlled Split-Mouth Clinical Trial

What this Trial Is About

Researchers are evaluating the effectiveness of a natural bioactive gel called Sterify Gel® as an additional treatment to standard non-surgical therapy for peri-implantitis. Peri-implantitis is an inflammatory condition affecting tissues around dental implants that can cause bone loss and implant failure. This randomized controlled clinical trial uses a split-mouth design to compare outcomes in patients with at least two affected implants in different mouth quadrants. Participants will receive two types of treatment: one implant site will get the standard non-surgical therapy plus the Sterify Gel®, while the other implant site will be treated with standard therapy alone. The standard therapy includes mechanical cleaning using ultrasonic and manual instruments, followed by air-polishing with erythritol and glycine powders. The gel is applied into the peri-implant pocket using a sterile needle at baseline and during follow-up visits at 1, 3, 6, and 9 months. During the 9-month study period, researchers will assess clinical outcomes such as plaque levels, bleeding on probing, probing depth, suppuration, implant mobility, gingival bleeding, mucosal conditions, mucosal margin changes, and bone loss through regular examinations. Participants will attend follow-up visits at these intervals for treatment application and detailed assessments to monitor changes. The study aims to determine if adding the Sterify Gel® improves results compared to standard treatment alone.

Natural Bioactive Gel for Peri-Implantitis