Evaluating Sterify Gel Added to Standard Non-Surgical Treatment for Peri-Implantitis A Randomized Split-Mouth Trial in Adults with Dental Implants

What this Trial Is About

Researchers are evaluating the effectiveness of Sterify Gel4, a natural bioactive mucoadhesive gel, as an addition to standard non-surgical therapy for peri-implantitis. This inflammatory condition affects tissues around dental implants and can cause bone loss and implant failure. The trial uses a randomized controlled split-mouth design to compare clinical outcomes with and without the gel in adults aged 18 to 70 years who have peri-implantitis affecting at least two implants in different quadrants. Participants will receive standard non-surgical treatment, including mechanical debridement with ultrasonic and manual instruments and air-polishing with erythritol and glycine powders. One implant site per participant will also receive Sterify Gel applied into the peri-implant pocket at baseline and at 1, 3, 6, and 9 months. The gel contains polyvinyl polymers, hydroxytyrosol, magnesium ascorbyl phosphate, and nisin. Participants are instructed to avoid rinsing, eating, or oral hygiene at treated sites for 2 hours after gel application and follow hygiene instructions for 48 hours. During the 9-month study, participants will attend visits at baseline, 1, 3, 6, and 9 months for treatment and assessments. Researchers will measure plaque levels, bleeding on probing, probing depth, suppuration, implant mobility, gingival bleeding, mucosal conditions, mucosal margin migration, and bone loss. These evaluations aim to determine whether Sterify Gel improves outcomes beyond standard therapy. Safety and adherence will be monitored throughout the study.

Natural Bioactive Gel for Peri-Implantitis