Actively Recruiting
Natural History of Advanced Chronic Liver Diseases
Led by Chinese University of Hong Kong · Updated on 2025-06-29
500
Participants Needed
1
Research Sites
583 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years. The primary outcome is incident hepatic events and liver-related mortality. Participants will undergo annual transient elastography examination.
CONDITIONS
Official Title
Natural History of Advanced Chronic Liver Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
-
Aged 18 or above
-
Known ACLD, defined by:
- LSM > 10kPa or
- Clinical cirrhosis, suggested by 1. ultrasonography of the hepatobiliary system shows features of cirrhosis (e.g. shrunken and nodular liver) and portal hypertension (e.g. dilated portal vein, portal-systemic collaterals or varices, splenomegaly, ascites). 2. Oesophagogastroduodenoscopy (OGD) shows presence of oesophageal varices (OV) and/or gastric varices (GV) and/or portal hypertensive gastropathy.
You will not qualify if you...
- Current or past history of hepatocellular carcinoma (HCC)
- History of liver transplantation
- Asplenism or history of splenectomy
- Serious medical illness with limited life expectancy of less than 6 months
- Pregnancy
- Unable to obtain or refusal of informed consent from patient
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
J
Jimmy CT Lai, MB ChB
CONTACT
A
Angel Chim, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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